For first life to be properly assembled, there has to be a perfect mix of both proper nucleotide orientation (all right-handed) and amino-acid orientation (all left-handed) in order for this to occur. For those who understand this, chains of both DNA and protein are extremely long.
All amino acids occur naturally in equal proportions of right versus left-handed. Researchers have not found on single means of "purifying" such a mixture. The same problem (albeit more complex) exists for nucleotides.
What this means? To create the first cell, not only would all of the hundreds of thousands of the right kinds of amino acids in the hundred-plus functional proteins required for the first cell have to suddenly show up at exactly the right place, at exactly the right time, but they would all have to be left-handed. You don't have to be a mathematician to understand how vast of a problem this is.
When you take time to truthfully consider all the things that had to all happen in a precise way at a precise point in time to allow the random origin of first life, the extremely small probabilities given by prominent scientists make sense.
Here's a summary.
- The first bacterium had to have a bare minimum of at least 10,000 amino acid "connections" (a minimum of 100 functional protein chains, each with a few hundred amino acids, far below what has been actually observed in nature).
- The problem repeats for the nucleotides, except the DNA chain is much longer. (Current observations of the simplest bacteria show about 500,000 base pairs, and each base pair is made up of six parts, for a total of 3 million components.)
- All connections had to happen at the same place.
- All components had to arrive at the same time.
- There was only so much time available.
- There was only so much matter available.
- There was only so much space available in which interactions could occur.
- There is a reasonable limit to the number of interactions between particles at a given point in time in a given place.
- In addition, to all the above, the order of and connections between amino acids and nucleotides had to be correct.
Each flip carries a probability of 50%, 1 out of 2. SO the probability of all flips occurring in a row was a 1 chance in 2 multiplied by itself 110,000 times. In other words, 1/2^110,000. The odds of scientific impossibility are much lower than this!
This is just one of many, many evidences that are out there. This is just one small aspect to first life as well. You would also have to look at time, material, etc. The odds are beyond scientific impossibility.